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KMID : 0931320040040020030
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대한상부위장관.헬리코박터학회지
2004 Volume.4 No. 2 p.30 ~ p.39
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Interleukin-1B (IL-1B) Polymorphisms and Gastric Mucosal Levels of IL-1β Cytokine in Korean Patients with Gastric Cancer
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Kim Kyung-Jin
Chang Young-Woon
Sohn Seong-Dong
Jang Jae-Young
Nam Ki-Deuk
Kim Nam-Hoon
Lee Sang-Gil
Joo Kwang-Ro
Dong Seok-Ho
Kim Hyo-Jong
Kim Byung-Ho
Lee Joung-Il
Chang Rin
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Abstract
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Background/Aims: Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1β and an increased risk of developing GC in a Korean population.
Methods: Polymorphisms of IL-1A-889, IL-1B-31, -511, and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1β cytokine was measured using an ELISA.
Results: The frequencies of IL-1A, IL-1B-511, IL-1B-31, and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR 2.2; 95% CI, 1.1∼4.3) compared with controls. As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1β levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C.
Conclusions: Thus the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1β production contributed to the development of intestinal-type GC in this Korean population. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2004;4:30-39)
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KEYWORD
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Gastric cancer, Interleukin-1B polymorphisms, IL-1β mucosal level
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